| Prof. Rytis Prekeris|
Director of Molecular Biology Graduate Program Department of Cell and Developmental Biology School of medicine. Anshutz Medical Campus, University of Colorado
How to make invadopodia: the role of cytoskeleton dynamics and localized protein degradation during cancer cell metastasis
Prof. Rytis Prekeris
One of the most fundamental challenges in cell biology is understanding how cells migrate in three-dimensional extracellular matrices at specific times and to specific locations. Cell migration helps shape all tissues and organs during development and the disruption of mechanisms that normally control migration dramatically enhance the lethality of cancers. Recent studies have demonstrated that coordinated remodeling of actin cytoskeleton and endocytic membrane traffic is a key step in cell migration during normal development, as well as during cancer metastasis. In this presentation I will describe the most recent work from our laboratory on understanding the molecular machinery governing migration and invasion of cancer cells.